By plane
Outagamie County Regional Airport (http://www.atwairport.com/) IATA: ATW serves the city of Appleton and surrounding communities with flights to six major hubs: Minneapolis, Detroit and Atlanta with Delta; Chicago and Denver with United; Milwaukee with Frontier/Midwest. Allegiant Air also offers limited direct flights to Appleton from Las Vegas and Orlando.
Ground transportation from the airport to downtown is limited to taxis. For a single person expect to pay around $15 dollars for the 15 minute ride although prices vary with each cab service. Hotels like the Radisson Hotel, Candlewood Suites and the Hampton Inn offer complimentary shuttle service to and from the airport.
By car
The primary roads into the metro Appleton area are US 41 and US 10. US 41 runs north-south on the west side of the city, and turns east-west across the north side of the city. US 41 connects to Green Bay to the northeast and Oshkosh, Fond du Lac, and Milwaukee to the south. WIS 441 loops from US 41 across the south and east sides of the metro Appleton area. US 10 is an east-west highway that connects to Manitowoc to the east, and Stevens Point/Wausau to the west.
By bus
Greyhound Bus offers daily service to Appleton via its Chicago-Green Bay bus route. With no transfers, Greyhound to/from Chicago will take about 5 hours while to/from Green Bay will take about 40 minutes.